A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease.
Objective
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
Study Arms
- Experimental: TQJ230
- Placebo Comparator: Placebo
Eligibility
- Lp(a) ≥ 70 mg/dL at the screening visit, measured at the Central laboratory
- Myocardial infarction: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
- Ischemic stroke: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
- Clinically significant symptomatic peripheral artery disease
