AB154CSP0002 – Arcus

A Phase 2 Study to Evaluate the Safety and Efficacy of AB122 Monotherapy, AB154 in Combination With AB122, and AB154 in Combination With AB122 and AB928 in Front-Line, Non-Small Cell Lung Cancer


This randomized Phase 2 open-label study will evaluate the safety and efficacy of Zimberelimab (AB122) monotherapy, AB154 in combination with Zimberelimab, and AB154 in combination with Zimberelimab and AB928 in front-line, PD-L1 positive, locally advanced or metastatic non-small cell lung cancer.

Study Arms

  • Experimental: Arm 1 (Zimberelimab Monotherapy) 
  • Experimental: Arm 2 (AB154 and Zimberelimab Combination Therapy
  • Experimental: Arm 3 (AB154, Zimberelimab, and AB928 Combination Therapy)


  • Male or female participants; age ≥ 18 years
  • Histologically confirmed squamous or nonsquamous, PD-L1 positive, NSCLC that is locally advanced or metastatic without sensitizing epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutation expression
  • Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
  • Must have at least 1 measurable lesion per RECIST v1.1
  • Adequate organ and marrow function